Description
Melanotan-2 (MT-II / Melanotan II)
Intended for laboratory research purposes only. Not for human consumption
Melanotan-2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), featuring a lactam bridge and D-phenylalanine substitution.
Key Chemical Details:
- CAS Number: 121062-08-6
- Molecular Formula: C₅₀H₆₉N₁₅O₉
- Molecular Weight: 1024.18–1024.2 g/mol (commonly listed as 1024.2; exact monoisotopic mass ≈1023.54 Da)
- Amino Acid Sequence (one-letter code): Ac-Nle-DHF RWK-NH₂ (cyclic via Asp-Lys lactam bridge; where Nle = norleucine, D-Phe = D-phenylalanine)
- Full sequence (three-letter code): Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
- N-terminal: Acetylated Norleucine (Ac-Nle); C-terminal: Amidated Lysine (part of the cycle)
- IUPAC/Full Chemical Name: (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide (or variants such as N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide cyclic (2→7)-peptide)
- PubChem CID: 92432
- Appearance (typical research grade): White to off-white lyophilized powder
- Solubility: Readily soluble in water (e.g., ≥0.7 mg/mL) and aqueous buffers; may require mild agitation for full dissolution
- Storage: Typically -20°C (as lyophilized powder for stability); avoid repeated freeze-thaw cycles and exposure to light/moisture
- Other Properties:
- Cyclic lactam structure (Asp5 to Lys10 bridge) for enhanced stability and receptor affinity
- Amphiphilic with hydrophobic (Trp, Phe) and hydrophilic/charged (Arg, His, Lys) residues
- High polarity from multiple basic (Arg, Lys) and polar (His) side chains
- Sensitive to proteases (reduced via cyclization and D-amino acid), heat, light, and extreme pH
Disclaimers
- Strictly for qualified laboratory research professionals.
- Not FDA-approved; no therapeutic, diagnostic, or human-use applications.
- Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
- Handle according to standard lab safety protocols.
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