Description
Intended for laboratory research purposes only. Not for human consumption
Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone (ACTH) fragment ACTH(4-10). It features a C-terminal Pro-Gly-Pro extension that significantly improves its metabolic stability and prolongs its biological activity compared to the native ACTH fragment. Semax is primarily researched for its neuroprotective, nootropic, neurotrophic, and anxiolytic effects.
Key Chemical Details:
- CAS Number: 80714-61-0
- Molecular Formula: C₃₇H₅₁N₉O₁₀S
- Molecular Weight: 813.92–813.93 g/mol
- Amino Acid Sequence (one-letter code): MEHFPGP
- Full sequence (three-letter code): Met-Glu-His-Phe-Pro-Gly-Pro
- N-terminal: Methionine (Met); C-terminal: Proline (Pro)
- IUPAC/Full Chemical Name: L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
- PubChem CID: 122178
- Appearance (typical research grade): White to off-white lyophilized powder
- Solubility: Readily soluble in water or aqueous buffers
- Storage: Typically -20°C (as lyophilized powder for long-term stability); avoid repeated freeze-thaw cycles
- Other Properties:
- Synthetic analog of ACTH(4-10) with Pro-Gly-Pro C-terminal modification for enhanced stability
- Short peptide with good blood-brain barrier penetration in research models
- Hydrophilic peptide that influences BDNF expression, neurotransmitter systems, and neuroprotection
- Sensitive to proteases, heat, light, and improper pH
Disclaimers:
- Strictly for qualified laboratory research professionals.
- Not FDA-approved in this context; no therapeutic, diagnostic, or human-use applications.
- Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
- Handle according to standard lab safety protocols.
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