Description

Intended for laboratory research purposes only. Not for human consumption

Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory tetrapeptide tuftsin. It is a regulatory peptide developed for research into anxiolytic, nootropic, and neuroprotective effects, with modifications that enhance metabolic stability compared to native tuftsin.

Key Chemical Details:

  • CAS Number: 129954-34-3
  • Molecular Formula: C₃₃H₅₇N₁₁O₉
  • Molecular Weight: 751.87–751.9 g/mol
  • Amino Acid Sequence (one-letter code): TKPRPGP
  • Full sequence (three-letter code): Thr-Lys-Pro-Arg-Pro-Gly-Pro
  • N-terminal: Threonine (Thr); C-terminal: Proline (Pro)
  • IUPAC/Full Chemical Name: L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline
  • PubChem CID: 11765600
  • Appearance (typical research grade): White to off-white lyophilized powder
  • Solubility: Readily soluble in water or aqueous buffers (may require gentle reconstitution protocols for research settings)
  • Storage: Typically -20°C (as lyophilized powder for long-term stability); avoid repeated freeze-thaw cycles
  • Other Properties:
    • Synthetic analog of tuftsin with C-terminal Pro-Gly-Pro extension for improved stability
    • Short half-life in circulation due to rapid enzymatic degradation
    • Hydrophilic peptide that modulates GABAergic transmission and BDNF expression in research models
    • Sensitive to proteases, heat, light, and improper pH

Disclaimers:

  • Strictly for qualified laboratory research professionals.
  • Not FDA-approved in this context; no therapeutic, diagnostic, or human-use applications.
  • Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
  • Handle according to standard lab safety protocols.
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