Description
GHK-Cu (Copper Tripeptide-1 / Prezatide Copper)
Intended for laboratory research purposes only. Not for human consumption
GHK-Cu is a naturally occurring tripeptide complexed with copper(II), consisting of glycyl-L-histidyl-L-lysine (GHK) bound to Cu²⁺.
Key Chemical Details:
- CAS Number: 89030-95-5 (for the copper complex; related 49557-75-7 for some listings)
- Molecular Formula: C₁₄H₂₂CuN₆O₄ (or C₁₄H₂₃CuN₆O₄⁺ / C₁₄H₂₁CuN₆O₄⁻ variants depending on ionization/protonation in database entries)
- Molecular Weight: 401.91 g/mol (commonly listed; some sources approximate 340.38 g/mol for the apo-peptide GHK without copper, or 400.90–402.92 g/mol for the complex)
- Amino Acid Sequence (one-letter code): GHK
- Full sequence (three-letter code): Gly-His-Lys
- N-terminal: Glycine (Gly); C-terminal: Lysine (Lys)
- IUPAC/Full Chemical Name: copper;(2S)-6-amino-2-[[(2S)-2-(2-aminoacetyl)azanidyl-3-(1H-imidazol-4-yl)propanoyl]amino]hexanoate (or variants such as 6-amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid copper complex)
- PubChem CID: 73587 (common for GHK-Cu / Prezatide copper; related entries include 342538 for GHK apo-peptide, 139035031 for copper tripeptide, 71587328 for Prezatide copper)
- Appearance (typical research grade): Blue to blue-green lyophilized powder (due to copper complex; apo-GHK is white/off-white)
- Solubility: Readily soluble in water (e.g., high solubility ~130 g/L reported for related forms) and aqueous buffers
- Storage: Typically -20°C (as lyophilized powder for stability); protect from light and moisture
- Other Properties:
- Strong copper-binding affinity (via histidine residue and other coordinating groups)
- Amphiphilic with charged (Lys amino group) and polar (His imidazole) regions
- pKa (approximate): ~3.11 (predicted for related groups)
- Hygroscopic; sensitive to light, heat, and pH extremes that may affect copper coordination
Disclaimers:
- Strictly for qualified laboratory research professionals.
- Not FDA-approved; no therapeutic, diagnostic, or human-use applications (commonly studied in cosmetic/dermatological research contexts but sold as RUO).
- Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, copper content, and contaminants.
- Handle according to standard lab safety protocols.
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