Description
Retatrutide
Intended for laboratory research purposes only. Not for human consumption
Retatrutide (LY3437943) is a synthetic 39-amino-acid linear polypeptide analog functioning as a triple agonist of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). It features non-coded amino acids (Aib at positions 2 and 20, α-methylleucine at position 13) for protease resistance and a C20 fatty diacid conjugated via a γ-Glu-(AEEA) linker to a modified lysine for extended half-life and albumin binding.
Key Chemical Details:
- CAS Number: 2381089-83-2
- Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈ (free base; some sources note slight variations for salts or protonation)
- Molecular Weight: 4731.3–4731.4 g/mol (commonly listed as 4731.33 or 4731; exact monoisotopic mass ≈4728.47 Da)
- Amino Acid Sequence (one-letter code): YA¹QGTFTSDYSIL²LDKK⁴AQA¹AFIEYLLEGGPSSGAPPPS(where ¹ = Aib [α-aminoisobutyric acid], ² = α-methylleucine [MeLeu or α-Me-Leu], ⁴ = Lys modified with γ-Glu-(AEEA)-C20 diacid linker; C-terminal amidated)
- Full sequence (three-letter code): Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys[Lys(γ-Glu-(AEEA)-C20 diacid)]-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
- N-terminal: Tyrosine (Tyr); C-terminal: Amidated Serine (Ser-NH₂)
- IUPAC/Full Chemical Name: (Very long systematic name reflecting the 39-residue branched peptide with lipidation; e.g., a complex descriptor starting with (2S)-2-[[…]]—see PubChem for complete string)
- PubChem CID: 171390338 (primary for Retatrutide; related entries for sodium salt or variants)
- Appearance (typical research grade): White to off-white lyophilized powder
- Solubility: Readily soluble in water or aqueous buffers (may require reconstitution protocols, often with mild pH adjustment for full dissolution in research settings)
- Storage: Typically -20°C (as lyophilized powder for stability); avoid repeated freeze-thaw cycles
- Other Properties:
- Triple incretin/glucagon mimetic with fatty acylation for prolonged duration (weekly in models)
- High molecular weight and polarity from extensive peptide chain, charged/polar residues, and hydrophilic linker
- Sensitive to proteases (reduced via Aib/α-Me-Leu substitutions and lipidation), heat, light, and improper pH
Disclaimers:
- Strictly for qualified laboratory research professionals.
- Not FDA-approved in this context; no therapeutic, diagnostic, or human-use applications
- Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
- Handle according to standard lab safety protocols.
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