PT 141 10MG

PT-141 (Bremelanotide)

Intended for laboratory research purposes only. Not for human consumption

PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It acts as a melanocortin receptor agonist (primarily MC3R and MC4R)

Key Chemical Details:

• CAS Number: 189691-06-3
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.2 g/mol (commonly listed as 1025.18 or 1025.2; exact monoisotopic mass ≈1024.52 Da)
• Amino Acid Sequence (one-letter code): Ac-Nle-cyclo[DHfRWK] (where Nle = norleucine, f = D-phenylalanine; cyclic via Asp-Lys lactam bridge)
• Full sequence (three-letter code): Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• N-terminal: Acetylated Norleucine (Ac-Nle); C-terminal: Carboxylic acid on Lys (part of the cycle; often listed as -OH but cyclic)
• IUPAC/Full Chemical Name: (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid (or similar variants reflecting the cyclic structure with N-acetylation)
• PubChem CID: 9941379
• Appearance (typical research grade): White to off-white lyophilized powder
• Solubility: Readily soluble in water (e.g., ≥1 mg/mL) and aqueous buffers; may require mild agitation for full dissolution
• Storage: Typically -20°C (as lyophilized powder for stability); avoid repeated freeze-thaw cycles and protect from light/moisture
• Other Properties:
  • Cyclic lactam structure (Asp5 to Lys10 bridge) for enhanced stability and receptor affinity
  • Amphiphilic with hydrophobic (Trp, Phe) and hydrophilic/charged (Arg, His, Lys) residues
  • High polarity from multiple basic (Arg, Lys) and polar (His) side chains
  • Sensitive to proteases (reduced via cyclization and D-amino acid), heat, light, and extreme pH

Disclaimers:

• Strictly for qualified laboratory research professionals.
• Not FDA-approved for research peptide use; no therapeutic, diagnostic, or human-use applications
• Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
• Handle according to standard lab safety protocols.