Description
Tirzepatide
Intended for laboratory research purposes only. Not for human consumption
Tirzepatide is a synthetic 39-amino-acid linear polypeptide analog acting as a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. It features two α-aminoisobutyric acid (Aib) substitutions for protease resistance, and a C20 fatty diacid moiety attached via a γ-Glu-(AEEA)₂ linker to Lys20 for extended half-life and albumin binding.
Key Chemical Details:
- CAS Number: 2023788-19-2
- Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
- Molecular Weight: 4813.5–4813.53 g/mol (commonly listed as 4813.53 or 4813; exact monoisotopic mass ≈4810.52 Da)
- Amino Acid Sequence (one-letter code): YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS (where X = Aib at positions 2 and 13; Lys20 is modified with the fatty acid linker: -γ-Glu-(AEEA)₂-Lys-C20 diacid)
- Full sequence (three-letter code): Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Ile-Ala-Gln-Lys(γ-Glu-(AEEA)₂-Lys-icosanedioyl)-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
- N-terminal: Tyrosine (Tyr); C-terminal: Amidated Serine (Ser-NH₂)
- IUPAC/Full Chemical Name: (Very long systematic name reflecting the 39-residue branched peptide with lipidation; e.g., a complex descriptor starting with (2S)-2-[[20-[[(5S)-6-[[…]]—see PubChem for complete string)
- PubChem CID: 163285897 (or related entries like 156588324, 166567236 for variants/salts)
- Appearance (typical research grade): White to off-white lyophilized powder
- Solubility: Readily soluble in water or aqueous buffers (may require reconstitution protocols for full dissolution in research settings)
- Storage: Typically -20°C (as lyophilized powder for stability); avoid repeated freeze-thaw cycles
- Other Properties:
- Dual incretin mimetic with fatty acylation for prolonged duration
- High molecular weight and polarity from extensive peptide chain, charged/polar residues, and hydrophilic linker
- Sensitive to proteases (reduced via Aib substitutions and cyclization-like stability from lipidation), heat, light, and improper pH
Disclaimers
- Strictly for qualified laboratory research professionals.
- Not FDA-approved in this context; no therapeutic, diagnostic, or human-use applications.
- Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
- Handle according to standard lab safety protocols.
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