SEMAGLUTIDE 5MG

Semaglutide

Intended for laboratory research purposes only. Not for human consumption

Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist analog, a synthetic polypeptide with modifications to native GLP-1(7-37) including Aib substitution at position 8, Arg at position 34, and a C-18 fatty diacid side chain acylated via a spacer at Lys26.

Key Chemical Details:

• CAS Number: 910463-68-2
• Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
• Molecular Weight: 4113.58–4114 g/mol (commonly listed as 4113.6 or 4114; exact monoisotopic mass ≈4111.12 Da)
• Amino Acid Sequence (one-letter code): HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG (where X = Aib / α-aminoisobutyric acid, a non-standard residue)
• Full sequence (three-letter code): His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly (with Lys26 acylated by the fatty acid spacer: -[2-(2-{2-[2-(2-{2-[(S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butyrylamino]ethoxy}ethoxy)acetylamino]ethoxy}ethoxy)acetyl]-)
• N-terminal: Histidine (His); C-terminal: Glycine (Gly)
• IUPAC/Full Chemical Name: 18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-18-oxooctadecanoic acid (or similar systematic variants reflecting the full branched structure)
• PubChem CID: 56843331
• Appearance (typical research grade): White to off-white lyophilized powder
• Solubility: Readily soluble in water or aqueous buffers (may require reconstitution protocols for full dissolution in research settings)
• Storage: Typically -20°C (as lyophilized powder for stability); avoid repeated freeze-thaw cycles
• Other Properties:
  • Modified peptide with fatty acid acylation for extended half-life and albumin binding
  • High molecular weight and polarity due to extensive peptide chain and hydrophilic spacer
  • Sensitive to proteases (reduced degradation via modifications), heat, light, and improper pH

Disclaimers:

• Strictly for qualified laboratory research professionals.
• Not FDA-approved in this context; no therapeutic, diagnostic, or human-use applications
• Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
• Handle according to standard lab safety protocols.