MOTS-C 10MG

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

Intended for laboratory research purposes only. Not for human consumption

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the mitochondrial 12S rRNA gene.

Key Chemical Details:

• CAS Number: 1627580-64-6
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2174.6 g/mol (commonly listed as 2174.6 or 2174.62; exact monoisotopic mass ≈2174.07 Da, varying slightly by source)
• Amino Acid Sequence (one-letter code): MRWQEMGYIFYPRKLR
• Full sequence (three-letter code): Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• N-terminal: Methionine (Met); C-terminal: Arginine (Arg)
• IUPAC/Full Chemical Name: (4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid (or similar variants; long systematic name for the linear peptide chain)
• PubChem CID: 146675088 (primary entry; some related entries like 155885767 for human variant)
• Appearance (typical research grade): White to off-white lyophilized powder
• Solubility: Readily soluble in water
• Storage: Typically -20°C (as lyophilized powder for stability); avoid repeated freeze-thaw cycles
• Other Properties:
  • Amphiphilic (due to mix of hydrophobic, hydrophilic, and charged residues)
  • High polarity from multiple Arg/Lys (basic) and Glu/Gln (acidic/amidic) residues
  • Contains two methionine (Met) residues with sulfur (contributing to S atoms in formula)
  • Predicted properties (approximate): High hydrogen bond donors/acceptors; suitable for cellular uptake studies
  • Elemental composition (approximate %): Varies but dominated by C, H, N, O, with ~2 S atoms

Disclaimers :

• Strictly for qualified laboratory research professionals.
• Not FDA-approved; no therapeutic, diagnostic, or human-use applications.
• Purity typically ≥98–99% (HPLC); batch-specific third-party Certificates of Analysis (COAs) available for identity, purity, and contaminants.
• Handle according to standard lab safety protocols.